Our technology has been developed at Professor Heli Skottman's Lab in Tampere University, where academic research still continues to develop new regenerative solutions for treating blindness.
Here are listed the relevant scientific publications depicting the technologies and intellectual property currently owned by StemSight.
Vattulainen, M., Ilmarinen, T., Viheriälä, T. et al. Corneal epithelial differentiation of human pluripotent stem cells generates ABCB5+ and ∆Np63α+ cells with limbal cell characteristics and high wound healing capacity. Stem Cell Res Ther 12, 609 (2021). https://doi.org/10.1186/s13287-021-02673-3 https://rdcu.be/c5Wjb
Grönroos, Pyry, Tanja Ilmarinen, and Heli Skottman. "Directed differentiation of human pluripotent stem cells towards corneal endothelial-like cells under defined conditions." Cells 10.2 (2021): 331. https://doi.org/10.3390/cells10020331
Vattulainen, M., Ilmarinen, T., Koivusalo, L. et al. Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potential. Stem Cell Res Ther 10, 236 (2019). https://doi.org/10.1186/s13287-019-1354-2
Hongisto, H., Ilmarinen, T., Vattulainen, M. et al. Xeno- and feeder-free differentiation of human pluripotent stem cells to two distinct ocular epithelial cell types using simple modifications of one method. Stem Cell Res Ther 8, 291 (2017). https://doi.org/10.1186/s13287-017-0738-4
Mikhailova, Alexandra, et al. "Human pluripotent stem cell-derived limbal epithelial stem cells on bioengineered matrices for corneal reconstruction." Experimental eye research 146 (2016): 26-34. https://doi.org/10.1016/j.exer.2015.11.021
Mikhailova, Alexandra, et al. "Small-molecule induction promotes corneal epithelial cell differentiation from human induced pluripotent stem cells." Stem cell reports 2.2 (2014): 219-231. https://doi.org/10.1016/j.stemcr.2013.12.014