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Our technology has been developed at Professor Heli Skottman's Lab in Tampere University, where academic research still continues to develop new regenerative solutions for treating blindness. 

Here are listed the relevant scientific publications highlighting the technologies and intellectual property currently owned by StemSight.

Scientific publications

Kauppila, M., Mörö, A., et al.  Toward Corneal Limbus In Vitro Model: Regulation of hPSC-LSC Phenotype by Matrix Stiffness and Topography During Cell Differentiation Process. Advanced Healthcare Materials, 2301396 (2023).

Vattulainen, M., Ilmarinen, T., Viheriälä, T. et al. Corneal epithelial differentiation of human pluripotent stem cells generates ABCB5+ and ∆Np63α+ cells with limbal cell characteristics and high wound healing capacity. Stem Cell Res Ther 12, 609 (2021).

Grönroos, P., Ilmarinen, T. and Skottman, H. "Directed differentiation of human pluripotent stem cells towards corneal endothelial-like cells under defined conditions." Cells 10.2 (2021): 331.

Hongisto, H., Ilmarinen, T., Vattulainen, M. et al. Xeno- and feeder-free differentiation of human pluripotent stem cells to two distinct ocular epithelial cell types using simple modifications of one method. Stem Cell Res Ther 8, 291 (2017).

Vattulainen, M., Ilmarinen, T., Koivusalo, L. et al. Modulation of Wnt/BMP pathways during corneal differentiation of hPSC maintains ABCG2-positive LSC population that demonstrates increased regenerative potential. Stem Cell Res Ther 10, 236 (2019). 

Koivusalo, L., Kauppila, M. et al. Tissue adhesive hyaluronic acid hydrogels for sutureless stem cell delivery and regeneration of corneal epithelium and stroma. Biomaterials 225 (2019) 119516.

Sorkio, A., Koch, L., Koivusalo, L., et al. Human stem cell based corneal tissue mimicking structures using laser-assisted 3D bioprinting and functional bioinks. Biomaterials 171 (2018) 57-71.

Mikhailova, A., et al. "Small-molecule induction promotes corneal epithelial cell differentiation from human induced pluripotent stem cells." Stem cell reports 2.2 (2014): 219-231.

Mikhailova, A., et al. "Human pluripotent stem cell-derived limbal epithelial stem cells on bioengineered matrices for corneal reconstruction." Experimental eye research 146 (2016): 26-34.

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